CD-PRIME™

About CD-PRIME™

 

CD-PRIME™ Platform offers automated protocols for the enrichment of CTCs (Circulating Tumor Cells), cfDNA (cell-free DNA), and EV (exosome) derived from cancer tissues.
The circulating tumor cells found in blood samples of patients can be utilized for the diagnosis and prognosis of cancer by highly precise genetic analysis and cell quantification. Our advanced microfluidics technology allows various scenarios of liquid biopsy or simultaneous analyses of analytes.

Strengths

Quick and easy access to living CTCs using untreated blood and avoiding cross-contamination.

Full-automation

Without special pretreatment of the whole blood, it is possible to enrich living CTCs.

No contamination

Prevents cross-contamination of samples which may occur in various clinical situations.

Easy-to-use

Full automation of blood processing procedures does not require a high-level of training, and one can obtain CTCs and plasma simultaneously for a more sensitive liquid biopsy.

Fully certified

Registered as a Class 1 medical device to the Korean Ministry of Food and Drug Safety, US FDA (Food and Drug Administration), and CE (EU).

Would you like to learn more?

Get in touch with our experts and learn more about the application of the CD-Prime™

Isolations

According to the method of blood separation and isolation of targeted particles, different cartridges are provided.

Utility

  • To the maximum, four cartridges can be used as blood chamber
  • Up to 10ml whole blood can be inserted per one cartridge
  • Buffy coat separated from CD-LBx™ 1 can be compatible use with CD-FAST™ Auto for CTCs enrichment
  • Simultaneous prep of plasma (for cfDNA), buffy coat (for germline DNA), and CTCs
  • The end-user is able to do the downstream work such as NGS and PCR analysis according to target
  • Fully automatic separation by CD-OPR-2000™ device

Workflow

Utility

  • To the maximum, four cartridges can be used as blood chamber
  • Up to 10ml whole blood can be inserted per one cartridge
  • Inject Ficoll-Paque and whole blood into CD-LBx™​ 2 to separate PBMCs and plasma
  • Simultaneous prep of plasma (for cfDNA), PBMCs
  • The end-user is able to do the downstream work such as NGS and PCR analysis according to target
  • Fully automatic separation by CD-OPR-2000™ device

Workflow

2

Core technology

In the CD-PRIME™ system, the whole blood sample is injected into the inlet of the loading chamber, and target CTCs are trapped on a membrane while the microfluidic disc rotates.

User scenario

Product

CD-Lbx™ 1

CD-Lbx™ 2

CD-FAST™ Auto

CD-OPR-2000™

Required capacity

CD-Lbx™ 1

5-10 ml

CD-Lbx™ 2

5-10 ml

CD-FAST™ Auto

≤ 3 ml

or Buffy coat from CD-LBx™ 1

CD-OPR-2000™

-

CTC

CD-Lbx™ 1

-

CD-Lbx™ 2

-

CD-FAST™ Auto

CD-OPR-2000™

Plasma

CD-Lbx™ 1

CD-Lbx™ 2

CD-FAST™ Auto

-

CD-OPR-2000™

Buffy coat

CD-Lbx™ 1

CD-Lbx™ 2

CD-FAST™ Auto

-

CD-OPR-2000™

PBMC

CD-Lbx™ 1

-

CD-Lbx™ 2

-

CD-FAST™ Auto

-

CD-OPR-2000™

Platform

CD-Lbx™ 1

CD-OPR-2000™
(Automatic Platform)

CD-Lbx™ 2

CD-OPR-2000™
(Automatic Platform)

CD-FAST™ Auto

CD-OPR-2000™
(Automatic Platform)

CD-OPR-2000™

CD-OPR-2000™
(Automatic Platform)

What is the Liquid Biopsy from
Clinomics suitable for?

With the help of this technique, the CTCs, ctDNA, and EVs can be isolated easily; therefore, we can get more precise information about cancer’s progress.

  • CTCs give information about the cell morphology and it could be used for If, FISH and Functional assay.
  • ctDNA is favorable for early detection of cancer and response monitoring and surveillance of cancer.
  • EV (including exosomes) and CTCs are suitable for DNA, RNA and protein biomarkers investigation.

CD-Prime™️: Liquid Biopsy-Based Applications for Cancer Diagnosis and Monitoring

Would you learn more about liquid biopsy, including the role of circulating tumor cells in clinical oncology? Would you like to receive more in-depth technical information about the CD-Prime device? Would you read about different circulating tumor cell isolation methods and their comparison? If so, download our scientific summary, in which you will get answers to all questions and even more.

For more details,
feel free to download
our following materials

CD-PRIME™

brochure

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